Chromatin and Epigenetics 1400-235CHiE

1. Introduction. Chromatin- structure and functions. 2,3. Histone modifications. 4. Histone variants. 5. DNA methylation. 6. Overview of methods used in chromatin biology. 7. Linker histones. 8. Nucleosomal and higher-order chromatin organization 9. Chromatin remodeling. 10. Non-coding RNAs. 11. Epigenetic gene silencing and Polycomb proteins. 12. Epigenetic regulation of animal and plant development. 13. Chromatin and cancer.

Main fields of studies for MISMaP

biology
biotechnology

Course coordinators

Paweł Kiełczykowski
Bartosz Pajek

Type of course

elective monographs

Mode

Classroom

Prerequisites (description)

Students should have basic knowledge about genetics and biochemistry. Completion of courses covering genetics, biochemistry, and molecular biology is recommended.

Learning outcomes

Students will improve their knowledge about chromatin-based mechanisms of gene regulation and epigenetic phenomena.

Assessment criteria

Exam in a written form (test, close-ended questions).

Practical placement

n/a

Bibliography

1. Epigenetics. C. David Allis, Thomas Jenuwein, Danny Reinberg. CSHL Press, 2007
2. Fundamental Molecular Biology. Lizabeth A. Allison. Wiley, 2011.
3. Recent articles from scientific journals provided by lecturers.